Guillaume Vogin, MD, PhD

CURRICULUM VITAE

Guillaume VOGIN, MD, PhD

Business address:

Institut de Cancérologie de Lorraine	UMR 7365 CNRS-Université de Lorraine, IMoPA
Department of radiation oncology	Biopôle de l’Université de Lorraine, Campus Biologie-Santé,
6, avenue de Bourgogne	9, Avenue de la forêt de Haye, CS 50184,
54511 – Vandœuvre-lès-Nancy Cedex, FRANCE	54505 Vandœuvre-lès-Nancy, FRANCE

Phone : +33-3. 83. 59. 84. 27

Fax : +33-3. 83. 59. 83. 91

E-mail : g.vogin@nancy.unicancer.fr

Current position: Associate Professor – Senior radiation oncologist – Nancy Medical School, Université de Lorraine

Fields of expertise: sarcomas, CNS malignancies, pediatrics, SBRT, proton- and carbon ion beam radiation, unusual toxicities of radiotherapy

Medical qualifications:

• MD (2010), Thesis: Light ions: an innovative anti-cancer weapon and a danger for manned spaceflights.
• Assistant professor, Nancy Medical School (2012-14)
• DESC de cancérologie, option Medical Treatments for Cancers (East Interregion; Nancy Medical School, Université de Lorraine, 2012)
• Board certification – radiation oncology (2010)
• Qualification in medical education (2016)
• Qualification in pediatric oncology; thesis: Impact of local strategy on tumor control and functional outcomes in localized Ewing’s tumors of the spine: a French retrospective study. (Paris 11 University, 2010)
• Qualification in radiation biology & protection (Paris 11 University) (2006)
• Qualification in Radioanatomy applied to oncology (Nancy Medical School, Université de Lorraine 2004)

Medical experience:

• 2010-2014 : National center of carbon ions radiotherapy ETOILE
• 2004-2010 : residency ; one semester at the Curie Institute (Paris) and at Lyon Comprehensice Cancer Center (Lyon)
• Observer at Massachussetts General Hospital radiotherapy and protontherapy department (Dr Thomas DELANEY, Boston, MA)

Academic appointments:

• 2016-: Associate professor
• 2014- Head of the Docimology Commission (Nancy Medical School, Université de Lorraine)
• Co-author of the National Repository of the French College of Oncology Teachers

Scientific Qualifications:

• 2010-2014: PhD, Lyon 1 University ; thesis : Improvement of the tolerance of radiotherapy with an individual radiobiological approach and a unified conceptual approach in hadrontherapy
• 2012 : GCP training ; Renewal in 2016s
• 2010- : French coordinator of the European project ULICE (Union for Light Ion Radiotherapy in Europe) WP2, 7, 9, 10, 11.
• 2009 : NASA Space Radiation Summer School 2009 (New York, USA)
• 2007-2008 : Master degree (Paris 11 University) ; research fellow, the Paw Lab : Genetic Screen for Zebrafish Mutants with Defects in Erythropoiesis (Harvard Medical School, Boston, USA)

 Scientific activity:

 Main research field: 60% of adults and 80% of children survive their cancer; Of the 175,000 patients treated with radiotherapy each year in France, 10-15% are confronted with an “unusual” and unpredictable toxicity profile that can lead to sequelae. In pediatrics in particular, the cumulative incidence of sequelae at ≥30 years after primary treatment reaches 73.4% and is increasing. The emphasis is now on the quality of survival and the detection of the most radiosensitive individuals – making it possible to personalize the radiotherapy protocols to individual radiosensitivity.

In this perspective, I develop projects with the team 1 of the UMR 7365 CNRS-UL (Isabelle BEHM-ANSMANT and Christiane BRANLANT) to decipher biological mechanisms of this radiosensitivity at the molecular level. New biomarkers are being investigated by studying the alternative splicing of pre-mRNAs and the expression of non-coding RNAs in the cells of patients who have experienced unusual side effects after radiotherapy. We collaborate closely with the ICL-basic research laboratory CNRS 7039 CRAN, the IBISA National Platform for Cellular and Tissue Optical Imaging, the Genomics Platform of the Luxembourg Institute of Health and the INSERM Unit 866 (Dijon).

Clinical studies:

• 2016 : PI SPLICI-RAD study [funding 250 000 €].
• 2015 : PI FIBROTHERME study [ funding AFRETH 250 000 €]
• 2015 : PI EGRADIS study [funding 10 000€]
• 2015 PI fundamental project mRNA & radiation [funding Ligue CCIR-GE 30 000€]
• 2013 : PI PREVIRAS study
• 2013 : PI ARPEGE biomarqueur study [funding SFCE 100 000€ + PHRC 252 000 €]

Publications :

• Nesseler JP, Peiffert D, Vogin G, Nickers P. [Cancer, radiotherapy and immune system]. Cancer Radiother. 2017 Jun;21(4):307-315.
• Gamelon-Bénichou C, Oldrini S, Charra-Brunaud C, Vogin G, Salleron J, Peiffert D. [Comparison of survival and chronic gastrointestinal toxicities in patients with locally advanced cervical cancer, treated by conventional or intensity-modulated radiation technique]. Cancer Radiother. 2017 Apr 27. pii: S1278-3218(17)30057-4.
• Oldrini G, Huertas A, Renard-Oldrini S, Taste-George H, Vogin G, Laurent V, Salleron J, Henrot P. Tumor response assessment by MRI following stereotactic body radiation therapy for hepatocellular carcinoma. PLoS One. 2017 Apr 25;12(4):e0176118. Faivre JC, Py JF, Vogin G, Martinage G, Salleron J, Royer P, Grandgirard N, Pasquier D, Thureau S. [Conformal radiotherapy for vertebral bone metastasis].Cancer Radiother. 2016 Sep 7
• Oldrini G, Leroux A, Vogin G, Rios M, Marchal F, Sirveaux F, Verhaeghe JL, Renard-Oldrini S, Lesanne G, Salleron J, Henrot P. Comparison of the histopathological results of the radioguided percutaneous microbiopsies and the operative specimens of soft tissue tumors of limbs, trunk and retroperitoneum. Presse Med. 2016 Sep 2.
• Vogin G, Golfier F, Hajri T, Leroux A, Weber B. A HELLP syndrome complicates a gestational trophoblastic neoplasia in a perimenopausal woman: a case report. BMC Cancer. 2016 Aug 2;16:573.
• Jumeau R, Renard-Oldrini S, Courrech F, Buchheit I, Oldrini G, Vogin G, Peiffert D. High dose rate brachytherapy with customized applicators for malignant facial skin lesions. Cancer Radiother. 2016 Jul;20(5):341-6.
• Fourquet J, Sunyach MP, Vilotte F, Le Péchoux C, Ranchère-Vince D, Bonvalot S, Coindre JM, Terrier P, Meeus P, Helfre S, Martin E, Vogin G, Biau J, Kao W, Noel G, Ducassou A, Llacer-Moscardo C, Stoeckle E, Penel N, Sargos P. Time interval between surgery and start of adjuvant radiotherapy in patients with soft tissue sarcoma: A retrospective analysis of 1131 cases from the French Sarcoma Group. Radiother Onco 2016 Jul;120(1):156-62
• Le Rhun E, Dhermain F, Vogin G, Reyns N, Metellus P. Radionecrosis after  stereotactic radiotherapy for brain metastases. Expert Rev Neurother. 2016 Aug;16(8):903-14
• Granzotto A*, Benadjaoud MA*, Vogin G* (1er coauteur), Devic C, Ferlazzo ML, Bodgi L et al. Influence of Nucleoshuttling of the ATM Protein in the Healthy Tissues Response to Radiation Therapy: Toward a Molecular Classification of Human Radiosensitivity. Int J Radiat Oncol Biol Phys, 2016, Vol. 94, Issue 3, p450–460 (IF 4,3)
• Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 2015 Sep 18. (IF 10,5)
• Oldrini G, Leroux A, Grignon B, Troufléau P, Boyer B, Renard-Oldrini S, Vogin G, Henrot P. [Liver biopsy: A cause of little described complication]. Presse Med. 2015 Sep;44(9):948-9. (IF 1,1)
• Oldrini G, Vogin G, Renard-Oldrini S, Taste-George H, Grignon B, Henrot P. [Post-therapeutics features of hepatocellular carcinoma treated by stereotactic body radiation therapy]. Presse Med. 2015 Sep;44(9):951-3.(IF 1,1)
• Huger S, Graff P, Marchesi V, Vogin G, Guinement L, Serre AA, Peiffert D. [Head and neck adaptive radiotherapy: A tool for the detection of patients requiring adaptive radiotherapy]. Cancer Radiother. 2015 Sep 3. (IF 1,4)
• Vogin G, Calugaru V, Bolle S, George B, Oldrini G, Habrand JL, Mammar H, Dendale R, Salleron J, Noël G, Feuvret L. Investigation of ectopic recurrent skull base and cervical chordomas: The Institut Curie’s proton therapy center experience. Head Neck. 2015 Sep 4. (IF 2,6)
• Oldrini G, Renard-Oldrini S, Vogin G, Marchal F, Grignon B, Henrot P. [Ascites, pleural effusion and ovarian lesion]. Presse Med. 2015 Aug 26. (IF 1,1)
• Thariat J, Clément-Colmou K, Vogin G, Beckendorf V, Ducassou A, Ali AM, Salas S, Saada E, Thyss A, Lapeyre M, Isambert N. [Radiation therapy of cardiacsarcomas]. Cancer Radiother. 2014 Mar;18(2):125-31 (IF 1,4)
• Ferlazzo ML, Sonzogni L, Granzotto A, Bodgi L, Lartin O, Devic C, Vogin G, Pereira S, Foray N. Mutations of the Huntington’s Disease Protein Impact on the ATM-Dependent Signaling and Repair Pathways of the Radiation-Induced DNA Double-Strand Breaks: Corrective Effect of Statins and Bisphosphonates. Mol Neurobiol. 2014 Jun;49(3):1200-11. (IF 5.4)
• Bodgi L, Granzotto A, Devic C, Vogin G, Lesne A, Bottollier-Depois JF, Victor JM, Maalouf M, Fares G, Foray N. A single formula to describe radiation-induced protein relocalization: towards a mathematical definition of individual radiosensitivity. J Theor Biol. 2013 Sep 21;333:135-45. (IF 3.2)
• Vogin G, Helfre S, Glorion C, Mosseri V, Mascard E, Oberlin O, Gaspar N. Local control and sequelae in localised Ewing tumours of the spine: A French retrospective study. Eur J Cancer. 2013 Apr;49(6):1314-23. (IF 5.3)
• Vogin G, Biston MC, Marchesi V, Amessis M, De Marzi L, Lacroix F, Leroy A, Gassa F, Zefkili S, Helfre S. [Localized Ewing sarcoma of the spine: a preliminary dose-escalation study comparing innovative radiation techniques in a single patient]. Cancer Radiother. 2013 Feb;17(1):26-33. (IF 1,4)
• Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G, Chen W, Chen C, Campagna DR, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey HA, Kaplan J, Paw BH. Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature. 2012 Nov 22;491(7425):608-12. (IF 38.6)
• Lam Cham Kee HX, Charra-Brunaud C, Cuny JF, Reigneau M, Vogin G, Peiffert D. [Case report of EPPER Syndrome (eosinophilic polymorphic pruritic eruption associated with radiotherapy) in a patient treated against endometrial cancer]. Cancer Radiother. 2013 Feb;17(1):54-7. (IF 1,4)
• Vogin G, Foray N. The law of Bergonié and Tribondeau: a nice formula for a first approximation. Int J Radiat Biol. 2013 Jan;89(1):2-8. (IF 2.1)
• Joubert A, Vogin G, Devic C, Granzotto A, Viau M, Maalouf M, Thomas C, Colin C, Foray N. [Radiation biology: major advances and perspectives for radiotherapy].Cancer Radiother. 2011 Aug;15(5):348-54. (IF 1,5)
• Vogin G. [Radiosensitivity, radiocurability and DNA repair]. Cancer Radiother. 2011 Jul;15(4):294-306. (IF 1,4)
• Granzotto A, Joubert A, Viau M, Devic C, Maalouf M, Thomas C, Vogin G, Malek K, Colin C, Balosso J, Foray [Individual response to ionising radiation: What predictive assay(s) to choose?]. C R Biol. 2011 Feb;334(2):140-57. (IF 1,2).

Books:

• 2011: Granzotto, Z. Bencokova, G. Vogin, C. Devic, A. Joubert, J. Balosso and N. Foray. DNA Double-Strand Breaks Repair and Signaling of Human Gliomas and Normal Brain Cells in Response to Radiation: Potential Impact of the ATM-and BRCA1- Dependent Pathways, Brain Tumors – Current and Emerging Therapeutic Strategies, Dr. Ana Lucia Abujamra (Ed.), ISBN: 978-953-307- 588-4, InTech
• 2008 : « 50 Dossiers, cancérologie et hématologie », éditions ESTEM, réédition en 2013 et 2015

Awards :

• 2017 : Albert Nelson Marquis Lifetime Achievement Award
• 2014 : Fondation des Treilles
• 2011 : Société Française de Pédiatrie
• 2011 : Prix de la Renaissance Française
• 2009 : prix Lucien Mallet
• 2007 : Fondation Nuovo-Soldati

Scientific societies:

• 2014- : SFRO
• 2012- : SFCE
• 2011- : SIRLAF
• 2010- : PROS (Pediatric Radiation Oncology Society)
• 2009- : junior member ESTRO (European Society of Therapeutic Radiation Oncology)
• 2008- : ASMA (International Aerospace Medical Association)

Reviewer :

• Journal of Neuro-Oncology
• European Journal of Cancer
• Radiation Oncology
• Radiotherapy Oncology
• JoVE
• International Journal of Low Radiation (IJLR)
• Cancer Radiothérapie
• Swiss Medical Weekly

Miscellaneous: Candidate astronaut, European Space Agency 2008 selection

Le 1/06/2017