We have been collaborating across the borders to investigate the feasibility of IMRT and IGRT to spare the normal organs in cancers of various anatomic sites. We have been successful to demonstrate that these new radiotherapy techniques can significantly decrease radiation dose to radio-sensitive organs without compromising cure rate. Our preliminary experience with elderly head and neck cancer patients undergoing chemotherapy and radiation for cure suggested that elderly patients tolerated treatment as well as younger patients. The expertise that we acquire over the years allow us to conduct clinical research to improve patient quality of life. This international collaborative effort between academic and private radiation oncology institutions may one day demonstrate that chronological age should not be the main factor to deny elderly cancer patients a chance for cure.